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COMPARE AND CONTRAST CONFORMAL PHOTON TREATMENT TECHNIQUES AND PROTON TREATMENTS FROM A RADIOBIOLOGICAL PERSPECTIVE.A 30 year old man had an orchidectomy for a seminoma of the testis and is to be treated with radiotherapy to the para-aortic and ipsilateral iliac region.

Compare and contrast conformal photon treatment techniques and proton treatments
from a RADIOBIOLOGICAL perspective

1 A 30 year old man had an orchidectomy for a seminoma of the testis and is to be
treated with radiotherapy to the para-aortic and ipsilateral iliac region. Inevitably some
scattered radiation will occur to the remaining testicle. Assuming that the remaining
testicle receives a total dose of approximately 0.5Gy,discuss the biological consequences
of such a dose. What advice would you give regarding future fertility and hazards to
progeny?
2 Compare and contrast conformal photon treatment techniques and proton treatments
from a RADIOBIOLOGICAL perspective.
3 A planning error resulted in the delivery of 4 Gy per fraction for a patient being treated
radically for tonsillar cancer. His treatment was stopped after 14 fractions to a dose of
54 Gy. His original prescription was for 70 Gy in 35 fractions over 7 weeks. Describe
the expected acute and late effects on all the sensitive tissues of relevance for the actual
and intended treatment and outline the potential risks in terms of tumour cure rates
arising from this error. (Assume all relevant late reacting tissues have an alpha/beta of 2
and acute reacting tissues and tumour a value of 10. Assume re-population begins at
16 days into treatment).
4 Cell loss is an important kinetic factor which contributes to the dynamic state of tumour
growth. Describe the various mechanisms by which cell loss occurs, how it is measured
in normal and neoplastic tissues and, in particular, the relevance of cell loss in tumour
growth pre-irradiation and post-irradiation
5 Write short notes on any three of the following:
a) Radiation effects on the parotid gland
b) Inflammatory Modulators of Radiation Reactions
c) Free Radicals
d) Radiation Pneumonitis arising from Chemoradiotherapy Treatment


 

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